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The cat spinal cord and brain stem contain multiple 5-HT2-like and alpha 2-like receptors. In this study, autoreceptors that regulate catecholamine release were characterized in the cat spinal cord. Stimulation of motoneurons, which reliably releases norepinephrine, evoked release of norepinephrine in the presence of cocaine, a drug that has high affinity for alpha 2-like receptors. The stimulation-evoked release of norepinephrine was significantly attenuated by the alpha 2-adrenergic receptor agonist clonidine and the alpha 2-adrenergic receptor antagonist yohimbine. Clonidine-induced inhibition of norepinephrine release was blocked by the alpha 2-adrenergic receptor antagonist idazoxan. In contrast, stimulation of motoneurons did not evoke release of norepinephrine in the presence of prazosin, which has high affinity for 5-HT2-like receptors. Since release of norepinephrine from sympathetic nerve terminals is known to inhibit spinal cord motoneurons, the present findings demonstrate that the alpha 2-adrenergic receptor may exert an inhibitory effect on spinal cord motoneuron activity. The large amount of 5-HT2-like receptors in the cat spinal cord may suggest that 5-HT2 receptors may have a role in norepinephrine release in the spinal cord.The terms “metallic glass” and “inverted microstructure glass” refer to materials that exhibit a non-crystalline crystalline-like structure as their final stable structure, typically on cooling. The microstructure and resulting properties of these materials are controlled by the glass formers, processing conditions, and the cooling rate. These materials exhibit microstructural transformations, including an increase in volume and a change in shape with increasing or decreasing temperature.
Several methods of producing metallic glasses have been explored. Some approaches utilize fast cooling rates that prevent crystallization and the formation of a crystalline solid solution in the liquid state. These glasses are typically based on Al, Zr, and Ti alloys. However, these processes have not been successfully
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